Target
Carboxypeptidase B2
Ligand
BDBM50135934
Substrate
n/a
Meas. Tech.
ChEMBL_45639 (CHEMBL655449)
IC50
2.7±n/a nM
Citation
 Barrow, JCNantermet, PGStauffer, SRNgo, PLSteinbeiser, MAMao, SSCarroll, SSBailey, CColussi, DBosserman, MBurlein, CCook, JJSitko, GTiller, PRMiller-Stein, CMRose, MMcMasters, DRVacca, JPSelnick, HG Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem 46:5294-7 (2003) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM50135934
Synonyms:
3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-imidazol-4-yl]-propionic acid | CHEMBL68399
Type:
Small organic molecule
Emp. Form.:
C16H22N4O2
Mol. Mass.:
302.3715
SMILES:
CC(C)CCn1cnc(c1)C(Cc1ccc(N)nc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: