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Target
Melanocortin receptor 4
Ligand
BDBM50136365
Substrate
n/a
Meas. Tech.
ChEBML_106329
IC50
10±n/a nM
Citation
 Ruel, R; Herpin, TF; Iben, L; Luo, G; Martel, A; Mason, H; Mattson, G; Poirier, B; Ruediger, EH; Shi, D; Thibault, C; Yu, G; Antal Zimanyi, I; Poindexter, GS; Macor, JE beta-alanine dipeptides as MC4R agonists. Bioorg Med Chem Lett 13:4341-4 (2003) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50136365
Synonyms:
CHEMBL337571 | N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-3-methylamino-propionamide
Type:
Small organic molecule
Emp. Form.:
C27H39ClN6O2
Mol. Mass.:
515.091
SMILES:
CNCCC(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC(Cn2cncn2)(CC1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: