Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50136403
Substrate
n/a
Meas. Tech.
ChEBML_105266
Ki
2.8±n/a nM
Citation
 Sun, LQ; Chen, J; Mattson, RJ; Epperson, JR; Deskus, JA; Li, WS; Takaki, K; Hodges, DB; Iben, L; Mahle, CD; Ortiz, A; Molstad, D; Ryan, E; Yeleswaram, K; Xu, C; Luo, G Heterocyclic aminopyrrolidine derivatives as melatoninergic agents. Bioorg Med Chem Lett 13:4381-4 (2003) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50136403
Synonyms:
CHEMBL139439 | Cyclopropanecarboxylic acid [(S)-1-(2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-yl]-amide
Type:
Small organic molecule
Emp. Form.:
C16H20N2O2
Mol. Mass.:
272.3422
SMILES:
O=C(N[C@H]1CCN(C1)c1cccc2OCCc12)C1CC1
Structure:
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