Reaction Details Report a problem with these data
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Ligand
BDBM50136939
Substrate
n/a
Meas. Tech.
ChEMBL_103130 (CHEMBL712301)
Ki
125±n/a nM
Citation
 Li, X; Chu, S; Feher, VA; Khalili, M; Nie, Z; Margosiak, S; Nikulin, V; Levin, J; Sprankle, KG; Tedder, ME; Almassy, R; Appelt, K; Yager, KM Structure-based design, synthesis, and antimicrobial activity of indazole-derived SAH/MTA nucleosidase inhibitors. J Med Chem 46:5663-73 (2003) [PubMed]  Article 
Target
Name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Synonyms:
5 -methylthioadenosine nucleosidase | 5'-methylthioadenosine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) | MTA/SAH nucleosidase | MTAN | MTNN_ECOLI | Methylthioadenosine Nucleosidase(MTAN) | P46 | S-adenosylhomocysteine nucleosidase | mtn | mtnN | pfs | yadA
Type:
Enzyme
Mol. Mass.:
24347.14
Organism:
Escherichia coli (strain K12)
Description:
P0AF12
Residue:
232
Sequence:
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
  
Inhibitor
Name:
BDBM50136939
Synonyms:
3'-Ethyl-biphenyl-3-sulfonic acid (7-isobutylamino-3-methyl-1H-indazol-5-yl)-amide | CHEMBL347181
Type:
Small organic molecule
Emp. Form.:
C26H30N4O2S
Mol. Mass.:
462.607
SMILES:
CCc1cccc(c1)-c1cccc(c1)S(=O)(=O)Nc1cc(NCC(C)C)c2[nH]nc(C)c2c1
Structure:
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