Reaction Details Report a problem with these data
Target
Glutamate receptor 4
Ligand
BDBM50137124
Substrate
n/a
Meas. Tech.
ChEMBL_90299 (CHEMBL698779)
IC50
>100000±n/a nM
Citation
 Valgeirsson, J; Nielsen, EŘ; Peters, D; Varming, T; Mathiesen, C; Kristensen, AS; Madsen, U 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. J Med Chem 46:5834-43 (2003) [PubMed]  Article 
Target
Name:
Glutamate receptor 4
Synonyms:
GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4
Type:
PROTEIN
Mol. Mass.:
100881.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468628
Residue:
902
Sequence:
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
  
Inhibitor
Name:
BDBM50137124
Synonyms:
4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid | 4-chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid | CHEMBL346524
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O3
Mol. Mass.:
340.76
SMILES:
OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: