Reaction Details Report a problem with these data
Target
Replication protein E1
Ligand
BDBM50137884
Substrate
n/a
Meas. Tech.
ChEBML_84985
IC50
740±n/a nM
Citation
Faucher, AM; White, PW; Brochu, C; Grand-Maître, C; Rancourt, J; Fazal, G Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase. J Med Chem 47:18-21 (2003) [PubMed] Article
More Info.:
Target
Name:
Replication protein E1
Synonyms:
E1 | VE1_HPV11
Type:
PROTEIN
Mol. Mass.:
73515.58
Organism:
Human papillomavirus type 11
Description:
ChEMBL_84985
Residue:
649
Sequence:
MADDSGTENEGSGCTGWFMVEAIVEHTTGTQISEDEEEEVEDSGYDMVDFIDDRHITQNSVEAQALFNRQEADAHYATVQDLKRKYLGSPYVSPISNVANAVESEISPRLDAIKLTTQPKKVKRRLFETRELTDSGYGYSEVEAATQVEKHGDPENGGDGQERDTGRDIEGEGVEHREAEAVDDSTREHADTSGILELLKCKDIRSTLHGKFKDCFGLSFVDLIRPFKSDRTTCADWVVAGFGIHHSIADAFQKLIEPLSLYAHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLGTLLNIPENHMLIEPPKIQSGVRALYWFRTGISNASTVIGEAPEWITRQTVIEHSLADSQFKLTEMVQWAYDNDICEESEIAFEYAQRGDFDSNARAFLNSNMQAKYVKDCAIMCRHYKHAEMKKMSIKQWIKYRGTKVDSVGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSCSHFWLQPLTDAKVALLDDATQPCWTYMDTYMRNLLDGNPMSIDRKHRALTLIKCPPLLVTSNIDISKEEKYKYLHSRVTTFTFPNPFPFDRNGNAVYELSDANWKCFFERLSSSLDIEDSEDEEDGSNSQAFRCVPGSVVRTL
Inhibitor
Name:
BDBM50137884
Synonyms:
(1,1-Difluoro-2-{3'-[(naphthalen-1-ylmethyl)-carbamoyl]-biphenyl-4-yl}-2-oxo-ethyl)-phosphonic acid | (1,1-Difluoro-2-{3'-[(naphthalen-1-ylmethyl)-carbamoyl]-biphenyl-4-yl}-2-oxoethyl)-phosphonic acid | CHEMBL178015
Type:
Small organic molecule
Emp. Form.:
C26H20F2NO5P
Mol. Mass.:
495.4113
SMILES:
OP(O)(=O)C(F)(F)C(=O)c1ccc(cc1)-c1cccc(c1)C(=O)NCc1cccc2ccccc12