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Target
Replication protein E1
Ligand
BDBM50137896
Substrate
n/a
Meas. Tech.
ChEBML_84985
IC50
67000±n/a nM
Citation
 Faucher, AM; White, PW; Brochu, C; Grand-Maître, C; Rancourt, J; Fazal, G Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase. J Med Chem 47:18-21 (2003) [PubMed]  Article 
Target
Name:
Replication protein E1
Synonyms:
E1 | VE1_HPV11
Type:
PROTEIN
Mol. Mass.:
73515.58
Organism:
Human papillomavirus type 11
Description:
ChEMBL_84985
Residue:
649
Sequence:
MADDSGTENEGSGCTGWFMVEAIVEHTTGTQISEDEEEEVEDSGYDMVDFIDDRHITQNSVEAQALFNRQEADAHYATVQDLKRKYLGSPYVSPISNVANAVESEISPRLDAIKLTTQPKKVKRRLFETRELTDSGYGYSEVEAATQVEKHGDPENGGDGQERDTGRDIEGEGVEHREAEAVDDSTREHADTSGILELLKCKDIRSTLHGKFKDCFGLSFVDLIRPFKSDRTTCADWVVAGFGIHHSIADAFQKLIEPLSLYAHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLGTLLNIPENHMLIEPPKIQSGVRALYWFRTGISNASTVIGEAPEWITRQTVIEHSLADSQFKLTEMVQWAYDNDICEESEIAFEYAQRGDFDSNARAFLNSNMQAKYVKDCAIMCRHYKHAEMKKMSIKQWIKYRGTKVDSVGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSCSHFWLQPLTDAKVALLDDATQPCWTYMDTYMRNLLDGNPMSIDRKHRALTLIKCPPLLVTSNIDISKEEKYKYLHSRVTTFTFPNPFPFDRNGNAVYELSDANWKCFFERLSSSLDIEDSEDEEDGSNSQAFRCVPGSVVRTL
  
Inhibitor
Name:
BDBM50137896
Synonyms:
(4-Phenethylamino-benzenesulfonyl)-acetic acid | CHEMBL360467
Type:
Small organic molecule
Emp. Form.:
C16H17NO4S
Mol. Mass.:
319.375
SMILES:
OC(=O)CS(=O)(=O)c1ccc(NCCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: