Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50137946
Substrate
n/a
Meas. Tech.
ChEBML_215011
IC50
4±n/a nM
Citation
 Cho, H; Murakami, K; Nakanishi, H; Fujisawa, A; Isoshima, H; Niwa, M; Hayakawa, K; Hase, Y; Uchida, I; Watanabe, H; Wakitani, K; Aisaka, K Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists. J Med Chem 47:101-9 (2003) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50137946
Synonyms:
Biphenyl-2-carboxylic acid [2-[2-(4-dimethylamino-piperidin-1-yl)-2-oxo-ethoxy]-4-(5,6,7,8-tetrahydro-thieno[3,2-b]azepine-4-carbonyl)-phenyl]-amide | CHEMBL177885
Type:
Small organic molecule
Emp. Form.:
C37H40N4O4S
Mol. Mass.:
636.803
SMILES:
CN(C)C1CCN(CC1)C(=O)COc1cc(ccc1NC(=O)c1ccccc1-c1ccccc1)C(=O)N1CCCCc2sccc12
Structure:
Search PDB for entries with ligand similarity: