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Target
Polyprenyl synthetase family protein
Ligand
BDBM50135833
Substrate
n/a
Meas. Tech.
ChEMBL_69823 (CHEMBL679572)
IC50
360±n/a nM
Citation
 Ghosh, S; Chan, JM; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; Croft, SL; Kemp, RG; Kobayashi, S; Nozaki, T; Oldfield, E Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem 47:175-87 (2003) [PubMed]  Article 
Target
Name:
Polyprenyl synthetase family protein
Synonyms:
Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase
Type:
PROTEIN
Mol. Mass.:
41078.35
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_330072
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTTQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM50135833
Synonyms:
(2-methylbutyl)aminomethylene-1,1-bisphosphonate | (2-methylbutylamino)methylenediphosphonic acid | (Bis-phosphono-methyl)-(2-methyl-butyl)-ammonium | CHEMBL56011 | [(2-Methyl-butylamino)-phosphono-methyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C6H17NO6P2
Mol. Mass.:
261.1498
SMILES:
CCC(C)CN=C(P(O)(O)O)P(O)(O)=O |w:5.4|
Structure:
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