Reaction Details Report a problem with these data
Target
Vitamin K-dependent protein C
Ligand
BDBM50138154
Substrate
n/a
Meas. Tech.
ChEBML_27849
IC50
>450±n/a nM
Citation
 Zhao, G; Bolton, SA; Kwon, C; Hartl, KS; Seiler, SM; Slusarchyk, WA; Sutton, JC; Bisacchi, GS Synthesis of potent and selective 2-azepanone inhibitors of human tryptase. Bioorg Med Chem Lett 14:309-12 (2003) [PubMed]  Article 
Target
Name:
Vitamin K-dependent protein C
Synonyms:
Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor
Type:
Enzyme
Mol. Mass.:
52067.73
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
461
Sequence:
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
  
Inhibitor
Name:
BDBM50138154
Synonyms:
Biphenyl-4-carboxylic acid {1-[(5-aminomethyl-2-methyl-phenylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-amide | CHEMBL104064
Type:
Small organic molecule
Emp. Form.:
C29H32N4O3
Mol. Mass.:
484.5894
SMILES:
Cc1ccc(CN)cc1NC(=O)CN1CCCCC(NC(=O)c2ccc(cc2)-c2ccccc2)C1=O
Structure:
Search PDB for entries with ligand similarity: