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Target
Serine protease 1
Ligand
BDBM50138161
Substrate
n/a
Meas. Tech.
ChEBML_212699
IC50
>170±n/a nM
Citation
 Zhao, G; Bolton, SA; Kwon, C; Hartl, KS; Seiler, SM; Slusarchyk, WA; Sutton, JC; Bisacchi, GS Synthesis of potent and selective 2-azepanone inhibitors of human tryptase. Bioorg Med Chem Lett 14:309-12 (2003) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50138161
Synonyms:
CHEMBL321466 | N-{1-[(3-Aminomethyl-phenylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-3,3-diphenyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C30H34N4O3
Mol. Mass.:
498.616
SMILES:
NCc1cccc(NC(=O)CN2CCCCC(NC(=O)CC(c3ccccc3)c3ccccc3)C2=O)c1
Structure:
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