Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50138421
Substrate
n/a
Meas. Tech.
ChEBML_88029
IC50
4000±n/a nM
Citation
 Wu, TY; Hassig, C; Wu, Y; Ding, S; Schultz, PG Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorg Med Chem Lett 14:449-53 (2003) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50138421
Synonyms:
7-(Formyl-hydroxy-amino)-heptanoic acid phenylamide | CHEMBL139193
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
ON(CCCCCCC(=O)Nc1ccccc1)C=O
Structure:
Search PDB for entries with ligand similarity: