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Target
Metabotropic glutamate receptor 3
Ligand
BDBM50004881
Substrate
n/a
Meas. Tech.
ChEMBL_106395 (CHEMBL717250)
EC50
>200000±n/a nM
Citation
 Collado, I; Pedregal, C; Bueno, AB; Marcos, A; González, R; Blanco-Urgoiti, J; Pérez-Castells, J; Schoepp, DD; Wright, RA; Johnson, BG; Kingston, AE; Moher, ED; Hoard, DW; Griffey, KI; Tizzano, JP (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. J Med Chem 47:456-66 (2004) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 3
Synonyms:
GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor
Type:
Protein
Mol. Mass.:
98971.84
Organism:
Rattus norvegicus (Rat)
Description:
P31422
Residue:
879
Sequence:
MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50004881
Synonyms:
(RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid | Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG) | CHEMBL277475 | PPG
Type:
Small organic molecule
Emp. Form.:
C8H10NO5P
Mol. Mass.:
231.1425
SMILES:
NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Structure:
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