Reaction Details Report a problem with these data
Target
G2/mitotic-specific cyclin-B1
Ligand
BDBM50140090
Substrate
n/a
Meas. Tech.
ChEMBL_144034 (CHEMBL872836)
IC50
12.6±n/a nM
Citation
 Loughnan, ML; Nicke, A; Jones, A; Adams, DJ; Alewood, PF; Lewis, RJ Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. J Med Chem 47:1234-41 (2004) [PubMed]  Article 
Target
Name:
G2/mitotic-specific cyclin-B1
Synonyms:
CCNB1_RAT | Ccnb1 | G2/mitotic-specific cyclin B1 | G2/mitotic-specific cyclin-B1
Type:
PROTEIN
Mol. Mass.:
47397.83
Organism:
Rattus norvegicus
Description:
ChEMBL_144034
Residue:
423
Sequence:
MALRVTRNTKINTENKAKVSMAGAKRVPVAVAASKPLLRSRTALGDIGNKVSEQSRIPLKKETKKLGSGTVTVKALPKPVDKVPVCEPEVELDEPEPEPVMEVKHSPEPILVDTPSPSPMETSGCAPAEEYLCQAFSDVILAVSDVDADDGGDPNLCSEYVKDIYAYLRQLEEEQSVRPKYLLGREVTGNMRAILIDWLIQVQMKFRLLQETMYMTVSIIDRFMQDSCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTKHQIRQMEMKILRVLNFSLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELSMLDYDMVHFAPSQIAAGAFCLALKILDNGEWTPTLQHYLSHTEESLLPVMQHLAKNIVMVNRGLTKHMTIKNKYATSKHAKISTLAQLNCTLVQNLSKAVTKA
  
Inhibitor
Name:
BDBM50140090
Synonyms:
CHEMBL217150 | RDPCCSNPVCTVHNPQIC*
Type:
Small organic molecule
Emp. Form.:
C65H99N19O22S4
Mol. Mass.:
1626.856
SMILES:
CC(C)C[C@@H](NC(=O)[C@@H](CO)NC(=O)[C@@H](CS)NC(=O)[C@@H](CS)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(N)=O
Structure:
Search PDB for entries with ligand similarity: