Target
Coagulation factor X
Ligand
BDBM50140437
Substrate
n/a
Meas. Tech.
ChEBML_48666
IC50
4±n/a nM
Citation
 Jia, ZJWu, YHuang, WZhang, PSong, YWoolfrey, JSinha, UArfsten, AEEdwards, STHutchaleelaha, AHollennbach, SJLambing, JLScarborough, RMZhu, BY 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett 14:1229-34 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50140437
Synonyms:
2-(6-Chloro-naphthalen-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(imino-piperidin-1-yl-methyl)-phenyl]-amide | CHEMBL277657
Type:
Small organic molecule
Emp. Form.:
C27H22ClF4N5O
Mol. Mass.:
543.943
SMILES:
Fc1cc(ccc1NC(=O)c1cc(nn1-c1ccc2cc(Cl)ccc2c1)C(F)(F)F)C(=N)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: