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Target
Serine protease 1
Ligand
BDBM50140413
Substrate
n/a
Meas. Tech.
ChEBML_213043
IC50
>10000±n/a nM
Citation
 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Song, Y; Woolfrey, J; Sinha, U; Arfsten, AE; Edwards, ST; Hutchaleelaha, A; Hollennbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors. Bioorg Med Chem Lett 14:1229-34 (2004) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50140413
Synonyms:
2-(3-Fluoro-naphthalen-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(imino-pyrrolidin-1-yl-methyl)-phenyl]-amide | 2-(3-Fluoro-naphthalen-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(N,N-dimethyl-carbamimidoyl)-2-fluoro-phenyl]-amide | CHEMBL279486
Type:
Small organic molecule
Emp. Form.:
C24H18F5N5O
Mol. Mass.:
487.4246
SMILES:
CN(C)C(=N)c1ccc(NC(=O)c2cc(nn2-c2cc3ccccc3cc2F)C(F)(F)F)c(F)c1
Structure:
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