Target
Phenylalanine--tRNA ligase alpha subunit
Ligand
BDBM50140711
Substrate
n/a
Meas. Tech.
ChEMBL_154872 (CHEMBL768846)
IC50
>100000±n/a nM
Citation
 Yu, XYFinn, JHill, JMWang, ZGKeith, DSilverman, JOliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg Med Chem Lett 14:1339-42 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase alpha subunit
Synonyms:
Phenylalanyl-tRNA synthetase alpha chain | SYFA_STRP8 | pheS
Type:
PROTEIN
Mol. Mass.:
39288.40
Organism:
Streptococcus pyogenes serotype M18
Description:
ChEMBL_154869
Residue:
347
Sequence:
MDLQAQLEELKTKTLETLQSLTGNHTKELQDLRVAVLGKKGSLTELLKGLKDLSNDLRPVVGKQVNEVRDLLTKAFEEQAKIVEAAKIQAQLDAESIDVTLPGRQMTLGHRHVLTQTSEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEEILLRTHTSPVQARTLDQHDFSKGPLKMVSPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMRDLKGTLEMIIKKMFGEERSIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVDAKEYSGFAFGLGQERIAMLRYGINDIRGFYQGDQRFSEQFN
  
Inhibitor
Name:
BDBM50140711
Synonyms:
5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'R,6a'S)-spiro[2,3-dihydro-1H-indene-2,1'-perhydropyrrolo[3,4-c]pyrrole]-4',6'-dione | CHEMBL281459 | CHEMBL433225
Type:
Small organic molecule
Emp. Form.:
C26H20Cl2N2O2
Mol. Mass.:
463.355
SMILES:
Oc1c2C(NC3(Cc4ccccc4C3)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Structure:
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