Reaction Details Report a problem with these data
Target
Phenylalanine--tRNA ligase alpha subunit
Ligand
BDBM50140713
Substrate
n/a
Meas. Tech.
ChEMBL_154872 (CHEMBL768846)
IC50
30000±n/a nM
Citation
 Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg Med Chem Lett 14:1339-42 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase alpha subunit
Synonyms:
Phenylalanyl-tRNA synthetase alpha chain | SYFA_STRP8 | pheS
Type:
PROTEIN
Mol. Mass.:
39288.40
Organism:
Streptococcus pyogenes serotype M18
Description:
ChEMBL_154869
Residue:
347
Sequence:
MDLQAQLEELKTKTLETLQSLTGNHTKELQDLRVAVLGKKGSLTELLKGLKDLSNDLRPVVGKQVNEVRDLLTKAFEEQAKIVEAAKIQAQLDAESIDVTLPGRQMTLGHRHVLTQTSEEIEDIFLGMGFQIVDGFEVEKDYYNFERMNLPKDHPARDMQDTFYITEEILLRTHTSPVQARTLDQHDFSKGPLKMVSPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMRDLKGTLEMIIKKMFGEERSIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVDAKEYSGFAFGLGQERIAMLRYGINDIRGFYQGDQRFSEQFN
  
Inhibitor
Name:
BDBM50140713
Synonyms:
4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,6aS)-perhydropyrrolo[3,4-c]pyrrole-1,3-dione | CHEMBL283594 | CHEMBL435161
Type:
Small organic molecule
Emp. Form.:
C25H18Cl2N2O3
Mol. Mass.:
465.328
SMILES:
Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Structure:
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