Target
Phenylalanine--tRNA ligase, mitochondrial
Ligand
BDBM50140729
Substrate
n/a
Meas. Tech.
ChEMBL_154871 (CHEMBL768845)
IC50
510±n/a nM
Citation
 Yu, XYFinn, JHill, JMWang, ZGKeith, DSilverman, JOliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett 14:1343-6 (2004) [PubMed]  Article 
Target
Name:
Phenylalanine--tRNA ligase, mitochondrial
Synonyms:
FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN
Type:
PROTEIN
Mol. Mass.:
52367.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154870
Residue:
451
Sequence:
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
  
Inhibitor
Name:
BDBM50140729
Synonyms:
13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-(1S,2R,9S,12S,13R,14R)-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3(8),4,6-triene-13-carboxamide | CHEMBL284654
Type:
Small organic molecule
Emp. Form.:
C26H19Cl2NO5
Mol. Mass.:
496.339
SMILES:
O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Structure:
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