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Target
ATP-dependent translocase ABCB1
Ligand
BDBM50140813
Substrate
n/a
Meas. Tech.
ChEMBL_147986 (CHEMBL754111)
IC50
23000±n/a nM
Citation
 Wang, S; Folkes, A; Chuckowree, I; Cockcroft, X; Sohal, S; Miller, W; Milton, J; Wren, SP; Vicker, N; Depledge, P; Scott, J; Smith, L; Jones, H; Mistry, P; Faint, R; Thompson, D; Cocks, S Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance. J Med Chem 47:1329-38 (2004) [PubMed]  Article 
Target
Name:
ATP-dependent translocase ABCB1
Synonyms:
ATP-binding cassette sub-family B member 1 | Abcb1 | Abcb1b | CD_antigen=CD243 | MDR1B_MOUSE | Mdr1 | Mdr1b | Multidrug resistance protein 1 | P-glycoprotein 1 | P-glycoprotein 1 and 3 (MDR1a/MDR1b) | Pgy1 | Pgy1-1
Type:
PROTEIN
Mol. Mass.:
141009.67
Organism:
Mus musculus
Description:
ChEMBL_474396
Residue:
1276
Sequence:
MEFEENLKGRADKNFSKMGKKSKKEKKEKKPAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVQAGAKRS
  
Inhibitor
Name:
BDBM50140813
Synonyms:
4-[4-(2-Oxo-2-phenyl-ethyl)-piperazin-1-yl]-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile | CHEMBL27834
Type:
Small organic molecule
Emp. Form.:
C23H24N6O
Mol. Mass.:
400.4763
SMILES:
O=C(CN1CCN(CC1)c1ncnc2c(C#N)c3CCCCn3c12)c1ccccc1
Structure:
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