Target
Tumor necrosis factor receptor superfamily member 1A
Ligand
BDBM50141548
Substrate
n/a
Meas. Tech.
ChEBML_224214
IC50
1000±n/a nM
Citation
 Meng, CQZheng, XSNi, LYe, ZSimpson, JEWorsencroft, KJHotema, MRWeingarten, MDSkudlarek, JWGilmore, JMHoong, LKHill, RRMarino, EMSuen, KLKunsch, CWasserman, MASikorski, JA Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett 14:1513-7 (2004) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 1A
Synonyms:
CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60
Type:
PROTEIN
Mol. Mass.:
50495.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1509419
Residue:
455
Sequence:
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
  
Inhibitor
Name:
BDBM50141548
Synonyms:
(E)-3-(5-Bromo-2-methoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone | CHEMBL289427
Type:
Small organic molecule
Emp. Form.:
C19H19BrO5
Mol. Mass.:
407.255
SMILES:
COc1ccc(Br)cc1\C=C\C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
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