Target
Coagulation factor X
Ligand
BDBM50142096
Substrate
n/a
Meas. Tech.
ChEBML_49138
IC50
2±n/a nM
Citation
 Zhang, PBao, LZuckett, JFGoldman, EAJia, ZJArfsten, AEdwards, SSinha, UHutchaleelaha, APark, GLambing, JLHollenbach, SJScarborough, RMZhu, BY Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs. Bioorg Med Chem Lett 14:983-7 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50142096
Synonyms:
3'-(N,N-Dimethyl-carbamimidoyl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide | CHEMBL368984
Type:
Small organic molecule
Emp. Form.:
C28H23Cl2N5O2
Mol. Mass.:
532.421
SMILES:
CN(C)C(=N)c1cccc(c1)-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1
Structure:
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