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Target
N-acetylated-alpha-linked acidic dipeptidase 2
Ligand
BDBM50143071
Substrate
n/a
Meas. Tech.
ChEMBL_71707 (CHEMBL680921)
Ki
>100000±n/a nM
Citation
 Kozikowski, AP; Zhang, J; Nan, F; Petukhov, PA; Grajkowska, E; Wroblewski, JT; Yamamoto, T; Bzdega, T; Wroblewska, B; Neale, JH Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem 47:1729-38 (2004) [PubMed]  Article 
Target
Name:
N-acetylated-alpha-linked acidic dipeptidase 2
Synonyms:
N-acetylated-alpha-linked acidic dipeptidase 2 | N-acetylated-alpha-linked acidic dipeptidase II | NAALAD2 | NAALADase II | NALD2_HUMAN
Type:
PROTEIN
Mol. Mass.:
83602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71707
Residue:
740
Sequence:
MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL
  
Inhibitor
Name:
BDBM50143071
Synonyms:
(S)-4-(3-{(S)-3-Carboxy-1-[1-(2-cyano-ethyl)-1H-tetrazol-5-yl]-propyl}-ureido)-4-[1-(2-cyano-ethyl)-1H-tetrazol-5-yl]-butyric acid | CHEMBL46445
Type:
Small organic molecule
Emp. Form.:
C17H22N12O5
Mol. Mass.:
474.434
SMILES:
OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)c1nnnn1CCC#N)c1nnnn1CCC#N
Structure:
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