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Target
Methionine--tRNA ligase, cytoplasmic
Ligand
BDBM50143329
Substrate
n/a
Meas. Tech.
ChEMBL_105282 (CHEMBL878198)
IC50
70±n/a nM
Citation
 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold. Bioorg Med Chem Lett 14:1909-11 (2004) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase, cytoplasmic
Synonyms:
MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN
Type:
PROTEIN
Mol. Mass.:
101110.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105283
Residue:
900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
  
Inhibitor
Name:
BDBM50143329
Synonyms:
(S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide | (S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-1-((2-(2,4-dichlorophenyl)-5-oxooxazol-4(5H)-ylidene)methyl)azetidine-2-carboxamide | CHEMBL57382
Type:
Small organic molecule
Emp. Form.:
C23H20Cl2N4O5
Mol. Mass.:
503.335
SMILES:
NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl |r,c:23|
Structure:
Search PDB for entries with ligand similarity: