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Target
Adenosylhomocysteinase
Ligand
BDBM50144205
Substrate
n/a
Meas. Tech.
ChEBML_196739
IC50
8900±n/a nM
Citation
 Kim, HO; Yoo, SJ; Ahn, HS; Choi, WJ; Moon, HR; Lee, KM; Chun, MW; Jeong, LS Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett 14:2091-3 (2004) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50144205
Synonyms:
(1S,2R,5S)-5-(6-Amino-purin-9-yl)-4-fluoro-cyclopent-3-ene-1,2-diol | CHEMBL63311
Type:
Small organic molecule
Emp. Form.:
C10H10FN5O2
Mol. Mass.:
251.2171
SMILES:
Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C=C1F |c:17|
Structure:
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