Reaction Details Report a problem with these data
Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Ligand
BDBM50144717
Substrate
n/a
Meas. Tech.
ChEBML_100168
IC50
8300.0±n/a nM
Citation
 Gong, B; Hong, F; Kohm, C; Jenkins, S; Tulinsky, J; Bhatt, R; De Vries, P; Singer, JW; Klein, P Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta. Bioorg Med Chem Lett 14:2303-8 (2004) [PubMed]  Article 
Target
Name:
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Synonyms:
1-acylglycerol-3-phosphate O-acyltransferase beta | AGPAT2 | PLCB_HUMAN
Type:
PROTEIN
Mol. Mass.:
30924.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321473
Residue:
278
Sequence:
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
  
Inhibitor
Name:
BDBM50144717
Synonyms:
3-[2-Amino-6-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-methyl-phenol | CHEMBL75203
Type:
Small organic molecule
Emp. Form.:
C17H15ClN4O
Mol. Mass.:
326.78
SMILES:
Cc1ccc(O)cc1-c1cc(Nc2ccc(Cl)cc2)nc(N)n1
Structure:
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