Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50145236
Substrate
n/a
Meas. Tech.
ChEBML_144159
IC50
6±n/a nM
Citation
 Rueeger, H; Gerspacher, M; Buehlmayer, P; Rigollier, P; Yamaguchi, Y; Schmidlin, T; Whitebread, S; Nuesslein-Hildesheim, B; Nick, H; Cricione, L Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett 14:2451-7 (2004) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50435.58
Organism:
Rat 6B
Description:
NPY-Y5 NPY5R Rat 6B::Q63634
Residue:
445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM50145236
Synonyms:
1-{4-[(9-Fluoro-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-ylamino)-methyl]-piperidin-1-yl}-pentan-1-one | CHEMBL82374
Type:
Small organic molecule
Emp. Form.:
C22H28FN3O2S
Mol. Mass.:
417.54
SMILES:
CCCCC(=O)N1CCC(CNc2nc-3c(CCOc4ccc(F)cc-34)s2)CC1
Structure:
Search PDB for entries with ligand similarity: