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Target
Vitamin D3 receptor
Ligand
BDBM50145538
Substrate
n/a
Meas. Tech.
ChEBML_214183
IC50
1.9±n/a nM
Citation
 Kato, Y; Nakano, Y; Sano, H; Tanatani, A; Kobayashi, H; Shimazawa, R; Koshino, H; Hashimoto, Y; Nagasawa, K Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist. Bioorg Med Chem Lett 14:2579-83 (2004) [PubMed]  Article 
Target
Name:
Vitamin D3 receptor
Synonyms:
NR1I1 | VDR | VDR_CHICK | Vitamin D receptor
Type:
PROTEIN
Mol. Mass.:
51292.53
Organism:
Gallus gallus
Description:
ChEMBL_214183
Residue:
451
Sequence:
MSELRGSWDEQQQSMAYLPDADMDTVAASTSLPDPAGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAMFTCPFNGDCKITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKESLKPKLSEEQQKVIDTLLEAHHKTFDTTYSDFNKFRPPVRSKFSSRMATHSSSVVSQDFSSEDSNDVFGSDAFAAFPEPMEPQMFSNLDLSEESDESPSMNIELPHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFTMEDMSWTCGSNDFKYKVSDVTQAGHSMDLLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPGVQDTSLVESIQDRLSDILQTYIRCRHPPPGSRLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPEHSMQLTPLVLEVFGNEIS
  
Inhibitor
Name:
BDBM50145538
Synonyms:
(S)-1-Benzyl-5-((R)-2-{(R)-4-[2-[(3S,5R)-3,5-dihydroxy-2-methylene-cyclohex-(E)-ylidene]-eth-(Z)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-hydroxy-3-methyl-pyrrolidin-2-one | CHEMBL314009
Type:
Small organic molecule
Emp. Form.:
C34H47NO4
Mol. Mass.:
533.7413
SMILES:
C[C@H](C[C@H]1C[C@](C)(O)C(=O)N1Cc1ccccc1)C1CCC2\C(CCC[C@]12C)=C/C=C1\C[C@@H](O)C[C@H](O)C1=C
Structure:
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