Target
NAD-dependent histone deacetylase SIR2
Ligand
BDBM50146045
Substrate
n/a
Meas. Tech.
ChEBML_202251
IC50
134000±n/a nM
Citation
 Posakony, JHirao, MStevens, SSimon, JABedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem 47:2635-44 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent histone deacetylase SIR2
Synonyms:
MAR1 | SIR2 | SIR2_YEAST
Type:
PROTEIN
Mol. Mass.:
63277.80
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_942450
Residue:
562
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
  
Inhibitor
Name:
BDBM50146045
Synonyms:
9-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEMBL314070
Type:
Small organic molecule
Emp. Form.:
C13H10O3
Mol. Mass.:
214.2167
SMILES:
Oc1ccc2ccc3OC(=O)CCc3c2c1
Structure:
Search PDB for entries with ligand similarity: