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Target
NAD-dependent histone deacetylase SIR2
Ligand
BDBM50146061
Substrate
n/a
Meas. Tech.
ChEBML_202251
IC50
86000±n/a nM
Citation
 Posakony, J; Hirao, M; Stevens, S; Simon, JA; Bedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem 47:2635-44 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent histone deacetylase SIR2
Synonyms:
MAR1 | SIR2 | SIR2_YEAST
Type:
PROTEIN
Mol. Mass.:
63277.80
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_942450
Residue:
562
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
  
Inhibitor
Name:
BDBM50146061
Synonyms:
CHEMBL89585 | {2-[2-(3-Oxo-2,3-dihydro-1H-benzo[f]chromen-5-yloxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C22H27NO6
Mol. Mass.:
401.4529
SMILES:
CC(C)(C)OC(=O)NCCOCCOc1cc2ccccc2c2CCC(=O)Oc12
Structure:
Search PDB for entries with ligand similarity: