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Target
NAD-dependent histone deacetylase SIR2
Ligand
BDBM50146068
Substrate
n/a
Meas. Tech.
ChEBML_202251
IC50
39000±n/a nM
Citation
 Posakony, J; Hirao, M; Stevens, S; Simon, JA; Bedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem 47:2635-44 (2004) [PubMed]  Article 
Target
Name:
NAD-dependent histone deacetylase SIR2
Synonyms:
MAR1 | SIR2 | SIR2_YEAST
Type:
PROTEIN
Mol. Mass.:
63277.80
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_942450
Residue:
562
Sequence:
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRETNTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNPSNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQALIGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKDKGVYVVTSDEHPKTL
  
Inhibitor
Name:
BDBM50146068
Synonyms:
7-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEMBL88830
Type:
Small organic molecule
Emp. Form.:
C14H12O3
Mol. Mass.:
228.2433
SMILES:
COc1cccc2c3CCC(=O)Oc3ccc12
Structure:
Search PDB for entries with ligand similarity: