Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50146094
Substrate
n/a
Meas. Tech.
ChEMBL_1303 (CHEMBL616680)
Ki
10.4±n/a nM
Citation
 Jurczyk, S; Klodzinska, M; Maryniak, E; Zajdel, P; Pawlowski, M; Tatarczynska, E; Klodzinska, A; Chojnacka-Wójcik, E; Bojarski, AJ; Charakchieva-Minol, S; Duszynska, B; Nowak, G; Maciag, D New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation. J Med Chem 47:2659-66 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50146094
Synonyms:
8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,3-dimethyl-1H,8H-1,3,4b,8,9-pentaaza-fluorene-2,4,7-trione | CHEMBL91588
Type:
Small organic molecule
Emp. Form.:
C24H29N7O4
Mol. Mass.:
479.5316
SMILES:
COc1ccccc1N1CCN(CCCn2c3nc4n(C)c(=O)n(C)c(=O)c4n3ccc2=O)CC1
Structure:
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