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Target
Complement C1s subcomponent
Ligand
BDBM50099918
Substrate
n/a
Meas. Tech.
ChEBML_48032
Ki
860.0±n/a nM
Citation
 Subasinghe, NL; Ali, F; Illig, CR; Jonathan Rudolph, M; Klein, S; Khalil, E; Soll, RM; Bone, RF; Spurlino, JC; DesJarlais, RL; Crysler, CS; Cummings, MD; Morris, PE; Kilpatrick, JM; Sudhakara Babu, Y A novel series of potent and selective small molecule inhibitors of the complement component C1s. Bioorg Med Chem Lett 14:3043-7 (2004) [PubMed]  Article 
Target
Name:
Complement C1s subcomponent
Synonyms:
C1 esterase | C1S | C1S_HUMAN | Complement C1s | Complement C1s subcomponent | Complement C1s subcomponent heavy chain | Complement C1s subcomponent light chain | Complement component 1 subcomponent s | Trypsin | complement component 1, s subcomponent
Type:
Protein
Mol. Mass.:
76657.91
Organism:
Homo sapiens (Human)
Description:
P09871
Residue:
688
Sequence:
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED
  
Inhibitor
Name:
BDBM50099918
Synonyms:
4-[4-(4-Chloro-3-nitro-phenyl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL413764
Type:
Small organic molecule
Emp. Form.:
C15H11ClN4O2S3
Mol. Mass.:
410.921
SMILES:
CSc1sc(cc1-c1nc(cs1)-c1ccc(Cl)c(c1)[N+]([O-])=O)C(N)=N
Structure:
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