Target
Hormone-sensitive lipase
Ligand
BDBM50147268
Substrate
n/a
Meas. Tech.
ChEBML_88045
IC50
480±n/a nM
Citation
 Lowe, DBMagnuson, SQi, NCampbell, AMCook, JHong, ZWang, MRodriguez, MAchebe, FKluender, HWong, WCBullock, WHSalhanick, AIWitman-Jones, TBowling, MEKeiper, CClairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett 14:3155-9 (2004) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN
Type:
Protein
Mol. Mass.:
116599.07
Organism:
Homo sapiens (Human)
Description:
Q05469
Residue:
1076
Sequence:
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
  
Inhibitor
Name:
BDBM50147268
Synonyms:
2-(4-(4-tert-butylphenyl)piperidine-1-carbonyl)-4-isopropyl-3-methylisoxazol-5(2H)-one | 2-[4-(4-tert-Butyl-phenyl)-piperidine-1-carbonyl]-4-isopropyl-3-methyl-2H-isoxazol-5-one | CHEMBL107412
Type:
Small organic molecule
Emp. Form.:
C23H32N2O3
Mol. Mass.:
384.5118
SMILES:
CC(C)c1c(C)n(oc1=O)C(=O)N1CCC(CC1)c1ccc(cc1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: