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Target
Protein kinase C gamma type
Ligand
BDBM50147467
Substrate
n/a
Meas. Tech.
ChEBML_153125
IC50
2800±n/a nM
Citation
 Zhang, HC; Ye, H; Conway, BR; Derian, CK; Addo, MF; Kuo, GH; Hecker, LR; Croll, DR; Li, J; Westover, L; Xu, JZ; Look, R; Demarest, KT; Andrade-Gordon, P; Damiano, BP; Maryanoff, BE 3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett 14:3245-50 (2004) [PubMed]  Article 
Target
Name:
Protein kinase C gamma type
Synonyms:
KPCG_HUMAN | PKC gamma | PKC-gamma | PKCG | PRKCG | Protein kinase C gamma | Protein kinase C gamma type | Protein kinase C, PKC; classical/novel | Protein kinase C, gamma
Type:
Enzyme
Mol. Mass.:
78458.05
Organism:
Human
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
697
Sequence:
MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
  
Inhibitor
Name:
BDBM50147467
Synonyms:
3-[1-(3-Dimethylamino-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-naphthalen-1-yl-pyrrole-2,5-dione | CHEMBL326688
Type:
Small organic molecule
Emp. Form.:
C26H24N4O2
Mol. Mass.:
424.4944
SMILES:
CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2cccnc12 |t:9|
Structure:
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