Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50147714
Substrate
n/a
Meas. Tech.
ChEMBL_201454 (CHEMBL807599)
IC50
1.8±n/a nM
Citation
 Hale, JJ; Neway, W; Mills, SG; Hajdu, R; Ann Keohane, C; Rosenbach, M; Milligan, J; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Koo, GC; Koprak, SL; Jackson, JJ; Rosen, H; Mandala, S Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorg Med Chem Lett 14:3351-5 (2004) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50147714
Synonyms:
CHEMBL432067 | Phosphoric acid mono-[2-amino-4-(4-octyl-phenyl)-butyl] ester
Type:
Small organic molecule
Emp. Form.:
C18H32NO4P
Mol. Mass.:
357.4247
SMILES:
CCCCCCCCc1ccc(CCC(N)COP(O)(O)=O)cc1
Structure:
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