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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50148104
Substrate
n/a
Meas. Tech.
ChEMBL_154206 (CHEMBL759451)
IC50
>15000±n/a nM
Citation
 Koyama, H; Miller, DJ; Boueres, JK; Desai, RC; Jones, AB; Berger, JP; MacNaul, KL; Kelly, LJ; Doebber, TW; Wu, MS; Zhou, G; Wang, PR; Ippolito, MC; Chao, YS; Agrawal, AK; Franklin, R; Heck, JV; Wright, SD; Moller, DE; Sahoo, SP (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. J Med Chem 47:3255-63 (2004) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50148104
Synonyms:
2-Ethyl-7-[3-(4-phenoxy-phenoxy)-propoxy]-chroman-2-carboxylic acid | CHEMBL419019
Type:
Small organic molecule
Emp. Form.:
C27H28O6
Mol. Mass.:
448.5076
SMILES:
CCC1(CCc2ccc(OCCCOc3ccc(Oc4ccccc4)cc3)cc2O1)C(O)=O
Structure:
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