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Target
Cathepsin K
Ligand
BDBM50148298
Substrate
n/a
Meas. Tech.
ChEBML_45556
IC50
0.500000±n/a nM
Citation
Boros, EE; Deaton, DN; Hassell, AM; McFadyen, RB; Miller, AB; Miller, LR; Paulick, MG; Shewchuk, LM; Thompson, JB; Willard, DH; Wright, LL Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett 14:3425-9 (2004) [PubMed] Article
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM50148298
Synonyms:
((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2-methyl-propyl ester | (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE | (R)-3-methyl-1-phenylbutan-2-yl (S)-1-oxohexan-2-ylcarbamate | CHEMBL113948
Type:
Small organic molecule
Emp. Form.:
C18H27NO3
Mol. Mass.:
305.4119
SMILES:
CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C(C)C)C=O