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Target
Dipeptidase 1
Ligand
BDBM50148530
Substrate
n/a
Meas. Tech.
ChEMBL_192703 (CHEMBL801733)
IC50
350±n/a nM
Citation
 Gurulingappa, H; Buckhalts, P; Kinzler, KW; Vogelstein, B; Khan, SR Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase. Bioorg Med Chem Lett 14:3531-3 (2004) [PubMed]  Article 
Target
Name:
Dipeptidase 1
Synonyms:
DPEP1 | DPEP1_HUMAN | Dehydropeptidase-I | Dehydropeptidase-I (DHP-1) | Dipeptidase 1 | MDP | Microsomal dipeptidase | RDP | Renal dipeptidase | hRDP
Type:
Protein
Mol. Mass.:
45670.34
Organism:
Homo sapiens (Human)
Description:
P16444
Residue:
411
Sequence:
MWSGWWLWPLVAVCTADFFRDEAERIMRDSPVIDGHNDLPWQLLDMFNNRLQDERANLTTLAGTHTNIPKLRAGFVGGQFWSVYTPCDTQNKDAVRRTLEQMDVVHRMCRMYPETFLYVTSSAGIRQAFREGKVASLIGVEGGHSIDSSLGVLRALYQLGMRYLTLTHSCNTPWADNWLVDTGDSEPQSQGLSPFGQRVVKELNRLGVLIDLAHVSVATMKATLQLSRAPVIFSHSSAYSVCASRRNVPDDVLRLVKQTDSLVMVNFYNNYISCTNKANLSQVADHLDHIKEVAGARAVGFGGDFDGVPRVPEGLEDVSKYPDLIAELLRRNWTEAEVKGALADNLLRVFEAVEQASNLTQAPEEEPIPLDQLGGSCRTHYGYSSGASSLHRHWGLLLASLAPLVLCLSLL
  
Inhibitor
Name:
BDBM50148530
Synonyms:
2-[(1-Amino-2-cyclohexyl-ethyl)-hydroxy-phosphinoylmethyl]-3-(3-chloro-4-fluoro-phenyl)-acrylic acid | CHEMBL119392 | CHEMBL334143
Type:
Small organic molecule
Emp. Form.:
C18H24ClFNO4P
Mol. Mass.:
403.813
SMILES:
OC(=O)C(Cc1ccc(F)c(Cl)c1)CP(O)(=O)C(=N)CC1CCCCC1
Structure:
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