Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50149144
Substrate
n/a
Meas. Tech.
ChEBML_143096
IC50
1700±n/a nM
Citation
 Tatsumi, R; Seio, K; Fujio, M; Katayama, J; Horikawa, T; Hashimoto, K; Tanaka, H (+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 14:3781-4 (2004) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50149144
Synonyms:
3-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophen-2-yl-propan-1-one | CHEMBL125092
Type:
Small organic molecule
Emp. Form.:
C18H21NOS
Mol. Mass.:
299.43
SMILES:
O=C(CCC1CN2CCC1CC2)c1cc2ccccc2s1 |(.03,1.51,;.03,-.03,;-1.31,-.8,;-2.64,-.02,;-3.99,-.78,;-3.99,-2.32,;-5.32,-3.09,;-4.88,-1.89,;-5.94,-1.18,;-5.32,-.01,;-6.66,-.78,;-6.66,-2.32,;1.36,-.8,;1.74,-2.29,;3.27,-2.39,;4.22,-3.62,;5.73,-3.41,;6.32,-1.97,;5.39,-.76,;3.84,-.97,;2.67,.02,)|
Structure:
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