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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50149280
Substrate
n/a
Meas. Tech.
ChEMBL_155618 (CHEMBL766353)
IC50
>50000±n/a nM
Citation
 Elokdah, H; Abou-Gharbia, M; Hennan, JK; McFarlane, G; Mugford, CP; Krishnamurthy, G; Crandall, DL Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem 47:3491-4 (2004) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50149280
Synonyms:
CHEMBL325696 | [1-(4-tert-Butyl-benzyl)-6-(4-trifluoromethoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acid
Type:
Small organic molecule
Emp. Form.:
C28H24F3NO4
Mol. Mass.:
495.4897
SMILES:
CC(C)(C)c1ccc(Cn2cc(C(=O)C(O)=O)c3ccc(cc23)-c2ccc(OC(F)(F)F)cc2)cc1
Structure:
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