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Target
D(2) dopamine receptor
Ligand
BDBM50152016
Substrate
n/a
Meas. Tech.
ChEMBL_305866 (CHEMBL831910)
IC50
<100±n/a nM
Citation
 Heinrich, T; Böttcher, H; Gericke, R; Bartoszyk, GD; Anzali, S; Seyfried, CA; Greiner, HE; Van Amsterdam, C Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. J Med Chem 47:4684-92 (2004) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50152016
Synonyms:
2-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-isophthalonitrile | CHEMBL189869
Type:
Small organic molecule
Emp. Form.:
C25H24N6
Mol. Mass.:
408.4983
SMILES:
N#Cc1ccc2[nH]cc(CCCCN3CCN(CC3)c3c(cccc3C#N)C#N)c2c1
Structure:
Search PDB for entries with ligand similarity: