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Target
Pro-cathepsin H
Ligand
BDBM50152526
Substrate
n/a
Meas. Tech.
ChEMBL_306357 (CHEMBL828234)
IC50
>2000±n/a nM
Citation
 Barrett, DG; Catalano, JG; Deaton, DN; Hassell, AM; Long, ST; Miller, AB; Miller, LR; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions. Bioorg Med Chem Lett 14:4897-902 (2004) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50152526
Synonyms:
(1-(3-phenylpropyl)cyclobutyl)methyl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | CHEMBL187687 | [(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid 1-(3-phenyl-propyl)-cyclobutylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C30H40N2O4
Mol. Mass.:
492.6496
SMILES:
CCCC[C@H](NC(=O)OCC1(CCCc2ccccc2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Structure:
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