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Target
Interstitial collagenase
Ligand
BDBM50152630
Substrate
n/a
Meas. Tech.
ChEMBL_302308 (CHEMBL874107)
Ki
64000±n/a nM
Citation
 Cook, GR; Manivannan, E; Underdahl, T; Lukacova, V; Zhang, Y; Balaz, S Synthesis and evaluation of novel oxazoline MMP inhibitors. Bioorg Med Chem Lett 14:4935-9 (2004) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50152630
Synonyms:
(4S,5S)-4-Phenylsulfanyl-2-p-tolyl-5-vinyl-4,5-dihydro-oxazole | CHEMBL184472
Type:
Small organic molecule
Emp. Form.:
C18H17NOS
Mol. Mass.:
295.399
SMILES:
Cc1ccc(cc1)C1=N[C@@H](Sc2ccccc2)[C@@H](O1)C=C |t:8|
Structure:
Search PDB for entries with ligand similarity: