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Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50153778
Substrate
n/a
Meas. Tech.
ChEMBL_310472 (CHEMBL834416)
EC50
60±n/a nM
Citation
 Li, Q; Wang, GT; Li, T; Gwaltney, SL; Woods, KW; Claiborne, A; Wang, X; Gu, W; Cohen, J; Stoll, VS; Hutchins, C; Frost, D; Rosenberg, SH; Sham, HL Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors. Bioorg Med Chem Lett 14:5371-6 (2004) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 38702
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
43994.09
Organism:
Mus musculus
Description:
EBI_10570
Residue:
377
Sequence:
MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV
  
Component 2
Name:
Protein farnesyltransferase subunit beta
Synonyms:
FNTB_MOUSE | Fntb | Protein farnesyltransferase
Type:
PROTEIN
Mol. Mass.:
48811.61
Organism:
Mus musculus
Description:
EBI_12341
Residue:
437
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD
  
Inhibitor
Name:
BDBM50153778
Synonyms:
6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imidazol-5-yl)methoxy)nicotinonitrile | 6-[3-(4-Cyano-3-naphthalen-1-yl-benzyl)-3H-imidazol-4-ylmethoxy]-nicotinonitrile | CHEMBL184916
Type:
Small organic molecule
Emp. Form.:
C28H19N5O
Mol. Mass.:
441.4834
SMILES:
N#Cc1ccc(OCc2cncn2Cc2ccc(C#N)c(c2)-c2cccc3ccccc23)nc1
Structure:
Search PDB for entries with ligand similarity: