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Target
C-C chemokine receptor type 2
Ligand
BDBM50153941
Substrate
n/a
Meas. Tech.
ChEMBL_305170 (CHEMBL832760)
IC50
26000±n/a nM
Citation
 Moree, WJ; Kataoka, K; Ramirez-Weinhouse, MM; Shiota, T; Imai, M; Sudo, M; Tsutsumi, T; Endo, N; Muroga, Y; Hada, T; Tanaka, H; Morita, T; Greene, J; Barnum, D; Saunders, J; Kato, Y; Myers, PL; Tarby, CM Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett 14:5413-6 (2004) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50153941
Synonyms:
4-Methyl-thiophene-2-carboxylic acid N''-(2-{2-[(3,3-diphenyl-propylamino)-methyl]-pyrrolidin-1-yl}-acetyl)-hydrazide | CHEMBL446178
Type:
Small organic molecule
Emp. Form.:
C28H34N4O2S
Mol. Mass.:
490.66
SMILES:
Cc1csc(c1)C(=O)NNC(=O)CN1CCCC1CNCCC(c1ccccc1)c1ccccc1
Structure:
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