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Target
Estrogen receptor beta
Ligand
BDBM50154055
Substrate
n/a
Meas. Tech.
ChEMBL_306448 (CHEMBL829092)
IC50
3.7±n/a nM
Citation
 Malamas, MS; Manas, ES; McDevitt, RE; Gunawan, I; Xu, ZB; Collini, MD; Miller, CP; Dinh, T; Henderson, RA; Keith, JC; Harris, HA Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem 47:5021-40 (2004) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2_MOUSE | Esr2 | Estrb | Estrb | Estrogen receptor | Estrogen receptor beta | Nr3a2 | Nuclear receptor subfamily 3 group A member 2
Type:
PROTEIN
Mol. Mass.:
59091.81
Organism:
Mus musculus
Description:
ChEMBL_306448
Residue:
530
Sequence:
MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
  
Inhibitor
Name:
BDBM50154055
Synonyms:
2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL | 2-(3-Fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol | 2-(3-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | CHEMBL450940
Type:
Small organic molecule
Emp. Form.:
C15H10FNO3
Mol. Mass.:
271.2432
SMILES:
Oc1cc(C=C)c2oc(nc2c1)-c1ccc(O)c(F)c1
Structure:
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