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Target
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Ligand
BDBM50155482
Substrate
n/a
Meas. Tech.
ChEMBL_305549 (CHEMBL828568)
IC50
4500±n/a nM
Citation
 Yee, SW; Simons, C Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorg Med Chem Lett 14:5651-4 (2004) [PubMed]  Article 
Target
Name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms:
CP24A_RAT | Cyp24 | Cyp24a1 | Cytochrome P450 24A1
Type:
PROTEIN
Mol. Mass.:
59467.61
Organism:
Rattus norvegicus
Description:
ChEMBL_305549
Residue:
514
Sequence:
MSCPIDKRRTLIAFLRRLRDLGQPPRSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR
  
Inhibitor
Name:
BDBM50155482
Synonyms:
2-(2,5-Bis-trifluoromethyl-benzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | 2-[2,5-di(trifluoromethyl)benzyl]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | CHEMBL185720
Type:
Small organic molecule
Emp. Form.:
C20H16F6O2
Mol. Mass.:
402.3303
SMILES:
COc1ccc2C(=O)C(Cc3cc(ccc3C(F)(F)F)C(F)(F)F)CCc2c1
Structure:
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