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Target
Steroid hormone receptor ERR1
Ligand
BDBM50155829
Substrate
n/a
Meas. Tech.
ChEMBL_305523 (CHEMBL827660)
IC50
2000±n/a nM
Citation
 Busch, BB; Stevens, WC; Martin, R; Ordentlich, P; Zhou, S; Sapp, DW; Horlick, RA; Mohan, R Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem 47:5593-6 (2004) [PubMed]  Article 
Target
Name:
Steroid hormone receptor ERR1
Synonyms:
ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
Type:
PROTEIN
Mol. Mass.:
45508.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1499891
Residue:
423
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
  
Inhibitor
Name:
BDBM50155829
Synonyms:
2-Cyano-N-[5-(4-dimethylamino-phenyl)-[1,3,4]thiadiazol-2-yl]-3-{4-[2-(2,6-dimethyl-phenoxy)-ethoxy]-3-methoxy-phenyl}-acrylamide | CHEMBL189393
Type:
Small organic molecule
Emp. Form.:
C31H31N5O4S
Mol. Mass.:
569.674
SMILES:
COc1cc(\C=C(/C#N)C(=O)Nc2nnc(s2)-c2ccc(cc2)N(C)C)ccc1OCCOc1c(C)cccc1C
Structure:
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