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Target
Cathepsin K
Ligand
BDBM19746
Substrate
n/a
Meas. Tech.
ChEMBL_306404 (CHEMBL828745)
IC50
6±n/a nM
Citation
 Altmann, E; Cowan-Jacob, SW; Missbach, M Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. J Med Chem 47:5833-6 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM19746
Synonyms:
6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile | CHEMBL363847 | NVP-ABE854 | Purine lead structure, 1
Type:
Small organic molecule
Emp. Form.:
C19H28N8
Mol. Mass.:
368.4792
SMILES:
CN1CCN(CCn2cnc3c(NC4CCCCC4)nc(nc23)C#N)CC1
Structure:
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